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Sildenafil is broken down in the liver by hepatic metabolism using cytochrome p450 enzymes, mainly CYP450 3A4(major route), but also by CYP2C9 (minor route) hepatic isoenzymes.

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Sildenafil is a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum.The major product of metabolisation by these enzymes is N-desmethylated sildenafil, which is metabolised further.You will need to know the names of the various regions of the alimentary canal buy discount female viagra 100 mg online pregnancy labor symptoms,.Female Viagra improves woman sexuality, increases sensitivity to.In the United States, Pfizer received two patents for sildenafil: one for its indication to treat cardiovascular disease (marketed as Revatio) and another for its indication to treat erectile dysfunction (marketed as Viagra).

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Sildenafil is excreted as metabolites predominantly in the feces (about 80% of administered oral dose) and to a lesser extent in the urine (around 13% of the administered oral dose).

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Professional athletes have been documented using sildenafil, believing the opening of their blood vessels will enrich their muscles.Caution is advised in those who have cardiovascular disease.There are also mouth spray preparations of sildenafil for faster onset of action.

Sildenafil protects cyclic guanosine monophosphate (cGMP) from degradation by cGMP-specific phosphodiesterase type 5 (PDE5) in the corpus cavernosum.Methylation of 3-propylpyrazole-5-carboxylic acid ethyl ester with hot dimethyl sulfate.Buying Generic Viagra Without Prescription. 50 Mg Viagra Price.It was initially studied for use in hypertension (high blood pressure) and angina pectoris (a symptom of ischaemic heart disease ).

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